SCHEMBL28067733

SCHEMBL28067733

C=C(C=O)C1C2CC3CC1CC(S(N)(=O)=O)(C3)C2

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 8/20 0.38
HSD11B2 P80365 6/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28067766 0.75 HSD11B1 (0.39) HSD11B1HSD11B2
SCHEMBL28067764 0.73
SCHEMBL1046456 0.72 HSD11B1 (0.42) HSD11B1HSD11B2
SCHEMBL7368463 0.71 LMNA (0.41) HSD11B1HSD11B2
SCHEMBL28067727 0.71
SCHEMBL30510464 0.66
SCHEMBL28148216 0.63 HSD11B1 (0.34) HSD11B1HSD11B2
SCHEMBL1223355 0.61 HSD11B1 (0.36) HSD11B1HSD11B2
Ethylene SCHEMBL1043237 0.61 EPHX2 (0.43) HSD11B1HSD11B2
SCHEMBL1046838 0.60 EPHX2 (0.46) HSD11B1HSD11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103242192-B The inhibitor of 11-beta-hydroxysteroid dehydrogenase 1 type enzyme ABBVIE INC. (US) 2016-05-04 CN disclosed