Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 3/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28068055 | 0.80 | MAOA (0.47) | MEN1KMT2AAPAF1TDP2NSD2 | |
| SCHEMBL16431665 | 0.80 | APAF1 (0.50) | APAF1TDP2NSD2CASP3PPP1CA | |
| SCHEMBL16431829 | 0.75 | APAF1 (0.48) | APAF1TDP2NSD2CASP3PPP1CA | |
| SCHEMBL8213907 | 0.75 | CYP3A4 (0.51) | APAF1TDP2NSD2CASP3PPP1CA | |
| SCHEMBL30789068 | 0.74 | MEN1 (0.59) | MEN1KMT2ATNFCYP1A2CYP3A4 | |
| SCHEMBL2460475 | 0.74 | MEN1 (0.66) | MEN1KMT2AAPAF1NSD2CASP3 | |
| SCHEMBL628689 | 0.74 | APAF1 (0.47) | APAF1TDP2NSD2CASP3PPP1CA | |
| SCHEMBL30789071 | 0.74 | MEN1 (0.46) | MEN1KMT2ATNFCYP1A2CYP3A4 | |
| Bromide SCHEMBL8002743 | 0.73 | MEN1 (0.60) | MEN1KMT2ACASP3SENP6PDGFRB | |
| Hydrochloric Acid SCHEMBL1022954 | 0.73 | MEN1 (0.64) | MEN1KMT2AAPAF1NSD2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105636953-A | 1,4-disubstituted pyridazine derivatives and their use for treating smn-deficiency-related conditions | NOVARTIS AG | 2016-06-01 | — | — | CN | disclosed |