Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28068054 | 0.80 | MEN1 (0.48) | MAOAAPAF1TDP2NSD2CASP3 | |
| SCHEMBL16431665 | 0.79 | APAF1 (0.50) | MAOAAPAF1TDP2NSD2CASP3 | |
| SCHEMBL8213907 | 0.74 | CYP3A4 (0.51) | MAOAAPAF1TDP2NSD2CASP3 | |
| SCHEMBL16431829 | 0.74 | APAF1 (0.48) | MAOAAPAF1TDP2NSD2CASP3 | |
| SCHEMBL9704225 | 0.74 | TRPA1 (0.51) | MAOAACHEKMT2AMEN1TNF | |
| SCHEMBL628689 | 0.73 | APAF1 (0.47) | MAOAAPAF1TDP2NSD2CASP3 | |
| SCHEMBL15049142 | 0.72 | SCN9A (0.37) | MAOAAPAF1TDP2NSD2CASP3 | |
| SCHEMBL10333393 | 0.72 | KLK7 (0.50) | MAOAAPAF1TDP2NSD2CASP3 | |
| SCHEMBL16432053 | 0.72 | LMNA (0.42) | MAOAAPAF1TDP2NSD2CASP3 | |
| SCHEMBL31571273 | 0.72 | CYP1A2 (0.47) | MAOAKMT2AKDM4ENPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105636953-A | 1,4-disubstituted pyridazine derivatives and their use for treating smn-deficiency-related conditions | NOVARTIS AG | 2016-06-01 | — | — | CN | disclosed |