Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | COMT | P21964 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | METAP1 | P53582 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | CCR1 | P32246 | 3/20 | 0.52 |
| ▸ | CCR5 | P51681 | 3/20 | 0.52 |
| ▸ | CCR8 | P51685 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27570425 | 0.81 | TSHR (0.68) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL28105074 | 0.80 | TSHR (0.66) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL580188 | 0.79 | MMP2 (0.59) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL28225007 | 0.79 | TSHR (0.59) | TSHRMMP2CHRM1COMTADRA1A | |
| Bromide SCHEMBL27032828 | 0.78 | MMP2 (0.57) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL28068061 | 0.77 | LMNA (0.52) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL27640890 | 0.77 | CCR1 (0.54) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL85419 | 0.77 | TSHR (0.56) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL1006162 | 0.75 | TSHR (0.55) | TSHRMMP2CHRM1COMTADRA1A | |
| Phenanthroline SCHEMBL19327240 | 0.75 | TSHR (0.91) | TSHRMMP2CHRM1COMTADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105636953-B | 1,4 dibasic pyridyl derivatives and its purposes for treating the illness related to SMN shortages | 诺华股份有限公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-105636953-A | 1,4-disubstituted pyridazine derivatives and their use for treating smn-deficiency-related conditions | NOVARTIS AG | 2016-06-01 | — | — | CN | disclosed |