Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 4/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL481946 | 0.88 | PAX8 (0.49) | PAX8CYP17A1F2BRD4KDM4E | |
| SCHEMBL16856539 | 0.87 | PAX8 (0.49) | PAX8LOXL2BRD4KDM4EKMT2A | |
| Potassium SCHEMBL30601778 | 0.87 | PAX8 (0.48) | PAX8CYP17A1F2BRD4KDM4E | |
| SCHEMBL14907964 | 0.79 | BRD4 (0.48) | PAX8LOXL2BRD4KMT2ACREBBP | |
| SCHEMBL8018111 | 0.77 | PAX8 (0.55) | PAX8BRD4KMT2ACREBBPLMNA | |
| SCHEMBL7433171 | 0.75 | MMP13 (0.48) | CYP17A1GPR119RAB9ANAMPT | |
| SCHEMBL15948302 | 0.74 | F2 (0.38) | PAX8CYP17A1F2KDM4EKMT2A | |
| SCHEMBL12812295 | 0.74 | KDM4E (0.59) | LOXL2KDM4EKMT2ALMNARAB9A | |
| SCHEMBL8336083 | 0.74 | CYP17A1 (0.44) | CYP17A1CYP19A1LMNAGPR119RAB9A | |
| SCHEMBL7531272 | 0.73 | PAX8 (0.50) | PAX8BRD4KMT2ACREBBPLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105693730-A | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors | 西格诺药品有限公司 | 2016-06-22 | — | — | CN | disclosed |