Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 3/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11962893 | 0.79 | UHRF1 (0.54) | CDC7ROCK2MAP4K4CDK2GSK3B | |
| SCHEMBL27861151 | 0.79 | DYRK1A (0.58) | MAP4K4DYRK1AWNT3APSEN1PSEN2 | |
| SCHEMBL4180341 | 0.78 | KDM4E (0.37) | — | |
| SCHEMBL22886737 | 0.76 | DYRK1A (0.44) | CDC7ROCK2MAP4K4CDK2GSK3B | |
| SCHEMBL18504874 | 0.76 | CCNC (0.43) | CDC7ROCK2MAP4K4CDK2GSK3B | |
| SCHEMBL883728 | 0.76 | — | — | |
| SCHEMBL28719887 | 0.75 | WNT3A (0.46) | DYRK1AWNT3APORCN | |
| SCHEMBL15317985 | 0.75 | KDM4E (0.44) | CYP3A4 | |
| SCHEMBL27343853 | 0.74 | CYP1A2 (0.44) | CLK4CYP2D6CYP3A4 | |
| SCHEMBL11951636 | 0.73 | LMNA (0.47) | CDC7ROCK2MAP4K4CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111349093-B | 5, 6-bicyclic compounds as WNT signal pathway inhibitors and medical application thereof | 汇瀚医疗科技有限公司 | 2021-07-02 | — | — | CN | disclosed |
| CN-111349093-A | 5, 6-bicyclic compounds as WNT signal pathway inhibitors and medical application thereof | 汇瀚医疗科技有限公司 | 2020-06-30 | — | — | CN | disclosed |
| CN-104379583-B | Compounds and compositions as WNT signaling inhibitors and uses thereof | 广州源生医药科技有限公司 | 2016-06-08 | — | — | CN | disclosed |