Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 6/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | NT5E | P21589 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27930461 | 0.71 | TAAR1 (0.43) | NT5E | |
| SCHEMBL1246822 | 0.70 | NPBWR1 (0.44) | — | |
| SCHEMBL27947333 | 0.70 | FGFR1 (0.43) | — | |
| SCHEMBL31497612 | 0.69 | TGFBR1 (0.44) | TGFBR1PIM1PIM3PIM2IDH1 | |
| SCHEMBL30627327 | 0.69 | TRPA1 (0.57) | TGFBR1PIM1 | |
| SCHEMBL27947326 | 0.68 | MAP4K4 (0.39) | — | |
| SCHEMBL19072795 | 0.68 | MPL (0.54) | TGFBR1IDH1IDH2NOTUMCOMT | |
| SCHEMBL30395354 | 0.68 | NOTUM (0.58) | IDH1IDH2NOTUMGABRA1GABRG2 | |
| SCHEMBL15624402 | 0.68 | NOTUM (0.58) | IDH1IDH2NOTUMGABRA1GABRG2 | |
| SCHEMBL22337449 | 0.68 | NOTUM (0.47) | TGFBR1IDH1IDH2NOTUMGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658645-A | Piperidinylbenzimidazole Derivatives as MPGE-1 Inhibitors | 诺瓦赛德股份公司 | 2016-06-08 | — | — | CN | disclosed |