Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.66 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.64 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.55 |
| ▸ | CDC7 | O00311 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
| ▸ | PRKACA | P17612 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.52 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 2/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.50 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15397138 | 0.92 | TGFBR1 (0.67) | TGFBR1IKBKETBK1PDPK1DYRK1B | |
| SCHEMBL5618155 | 0.86 | TGFBR1 (0.71) | TGFBR1IKBKETBK1PDPK1DYRK1B | |
| SCHEMBL15397129 | 0.83 | IKBKE (0.78) | TGFBR1IKBKETBK1PDPK1DYRK1B | |
| SCHEMBL198641 | 0.82 | MAPT (0.64) | — | |
| SCHEMBL16572576 | 0.81 | TGFBR1 (0.67) | TGFBR1IKBKETBK1PDPK1DYRK1B | |
| SCHEMBL15397133 | 0.80 | TGFBR1 (0.69) | TGFBR1IKBKETBK1PDPK1CDC7 | |
| SCHEMBL12501165 | 0.80 | TGFBR1 (1.00) | TGFBR1IKBKETBK1PDPK1DYRK1B | |
| SCHEMBL12501144 | 0.78 | IKBKE (1.00) | TGFBR1IKBKETBK1PDPK1DYRK1B | |
| SCHEMBL12501143 | 0.78 | TGFBR1 (1.00) | TGFBR1IKBKETBK1PDPK1DYRK1B | |
| SCHEMBL12501089 | 0.78 | TGFBR1 (0.63) | TGFBR1IKBKETBK1PDPK1DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105622605-A | Synthesis method of 5-bromo-7-azaindole | ITIC MEDCHEM CO LTD | 2016-06-01 | — | — | CN | claimed |
| CN-105622605-A | Synthesis method of 5-bromo-7-azaindole | ITIC MEDCHEM CO LTD | 2016-06-01 | — | — | CN | disclosed |