SCHEMBL28069216

SCHEMBL28069216

NCc1ccc(S(=O)(=O)c2nc(Cc3cccc(Cl)c3)ns2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNMT P11086 1/20 0.43
MAOB P27338 2/20 0.39
HTR6 P50406 2/20 0.37
TAAR1 Q96RJ0 2/20 0.37
TP53 P04637 1/20 0.36
PGR P06401 1/20 0.34
CCR2 P41597 1/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA12 O43570 1/20 0.34
CA4 P22748 1/20 0.34
CA6 P23280 1/20 0.34
CA5A P35218 1/20 0.34
CA7 P43166 1/20 0.34
CA9 Q16790 1/20 0.34
CA14 Q9ULX7 1/20 0.34
CA5B Q9Y2D0 1/20 0.34
HTR2C P28335 1/20 0.34
HTR2B P41595 1/20 0.34
PDE4B Q07343 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL799810 0.76 BCHE (0.47) CA1MAPT
SCHEMBL14755439 0.73 CYP3A4 (0.44) CA12CA9MAPT
SCHEMBL160410 0.71 PNMT (0.53) PNMTMAOBHTR6TAAR1PGR
SCHEMBL28069217 0.68 KDM4E (0.35) CA1CA2CA12CA4CA6
SCHEMBL1568853 0.68 CNR2 (0.47) CA1MAPT
SCHEMBL14937572 0.67 CA1 (0.63) PNMTPGRCA1CA2CA12
SCHEMBL6236661 0.65 PGR (0.52) PNMTTAAR1PGRCA1CA2
SCHEMBL5311 0.65
SCHEMBL29585607 0.65
SCHEMBL26090239 0.64 HTT (0.63) PNMTTAAR1TP53HTR2CMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102066347-B Thiadiazoles oxygen benzene carbon amidine and the application as antibacterial thereof 拜耳知识产权有限责任公司 2016-06-08 CN disclosed