Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.45 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.42 |
| ▸ | HTR3B | O95264 | 2/20 | 0.42 |
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14937572 | 0.85 | CA1 (0.63) | PGRCA1CA2CA9PNMT | |
| SCHEMBL9870772 | 0.83 | HTT (0.49) | CA1CA2CA9ALDH1A1 | |
| SCHEMBL776572 | 0.81 | CA1 (0.44) | CA1CA2CA9TAS2R14ALDH1A1 | |
| SCHEMBL3151100 | 0.81 | TSHR (0.62) | PGRCA1CA2CA9ALDH1A1 | |
| SCHEMBL9619529 | 0.81 | LMNA (0.56) | CA1CA2CA9KDM4EALDH1A1 | |
| SCHEMBL2093970 | 0.79 | PNMT (0.56) | PGRLTA4HPNMTDAOHTR3E | |
| Hydrochloric Acid SCHEMBL7261261 | 0.79 | LMNA (0.54) | CA1CA2CA9KDM4EALDH1A1 | |
| SCHEMBL3300276 | 0.79 | PNMT (0.65) | PNMTDAOCHRM2HTR3EHTR3B | |
| SCHEMBL11796800 | 0.78 | ESR1 (0.56) | LTA4HPNMTHCAR2HTR3EHTR3B | |
| SCHEMBL8992920 | 0.78 | PNMT (0.50) | PGRLTA4HPNMTDAOHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009384-A2 | EGFR TYROSINE KINASE INHIBITORS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |