Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696336 | 0.86 | ALDH1A1 (0.52) | ALOX15PDCD1CD274SETD7PDK1 | |
| SCHEMBL1120518 | 0.82 | GAA (0.53) | ALOX15RXFP1ALDH1A1MAPTKMT2A | |
| SCHEMBL1120688 | 0.80 | MAPT (0.59) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11813065 | 0.78 | SETD7 (0.52) | ALOX15PDCD1CD274SETD7PDK1 | |
| SCHEMBL2489141 | 0.76 | SCN8A (0.51) | PDCD1CD274SMN1; SMN2CNR2POLB | |
| SCHEMBL28001927 | 0.76 | PDCD1 (0.46) | ALOX15PDCD1CD274SETD7ALDH1A1 | |
| SCHEMBL9364693 | 0.76 | GPR35 (0.58) | ALOX15PDCD1CD274SETD7PDK1 | |
| Benzonitrile SCHEMBL9811793 | 0.75 | SMN1; SMN2 (0.53) | PDCD1CD274ALDH1A1MAPTKMT2A | |
| SCHEMBL23354683 | 0.74 | PDCD1 (0.45) | ALOX15PDCD1CD274SETD7PDK1 | |
| SCHEMBL5886102 | 0.74 | PDCD1 (0.45) | ALOX15PDCD1CD274SETD7PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104395312-B | The Spirocyclic derivatives of 4,5-dihydro-pyrazolo [3,4-c] pyridin-2-ones, its preparation method and application | SICHUAN HAISCO PHARMACEUTICAL CO.,LTD. (CN) | 2016-04-27 | — | — | CN | disclosed |