Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.31 |
| ▸ | HTR3B | O95264 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.31 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5699196 | 0.74 | HTR3E (0.41) | KMT2AKDM4EHTR3EHTR3BCHRM4 | |
| SCHEMBL28829472 | 0.71 | CYP2C9 (0.41) | CCR5TSHRKMT2AKDM4EPKM | |
| SCHEMBL6644570 | 0.70 | ALDH1A1 (0.39) | KMT2AKDM4EEPHX2MEN1SMN1; SMN2 | |
| SCHEMBL2904257 | 0.67 | MAPT (0.34) | KMT2AKDM4EMEN1 | |
| SCHEMBL2904253 | 0.67 | MAPT (0.34) | KMT2AKDM4EMEN1 | |
| SCHEMBL5204690 | 0.67 | MAPT (0.34) | KMT2AKDM4EMEN1 | |
| SCHEMBL2639019 | 0.67 | ALDH1A1 (0.37) | TSHRKMT2AMEN1 | |
| SCHEMBL5177356 | 0.66 | MEN1 (0.32) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6643716 | 0.66 | ERN1 (0.39) | TSHRKDM4E | |
| SCHEMBL2898740 | 0.66 | TSHR (0.44) | TSHRKMT2AKDM4EMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105801482-A | Method for preparing 1-cyclopropyl-4-oxo-7-bromine-8-difluoromethoxy-1,4-dihydro-quinoline-3-nonanoic acid-ethyl ester | 浙江中欣氟材股份有限公司 | 2016-07-27 | — | — | CN | claimed |
| CN-105777631-A | Synthesizing method of 1-cyclopropyl-4-oxo-7-bromo-8-difluoromethoxy-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester | 浙江中欣氟材股份有限公司 | 2016-07-20 | — | — | CN | claimed |
| CN-105801482-A | Method for preparing 1-cyclopropyl-4-oxo-7-bromine-8-difluoromethoxy-1,4-dihydro-quinoline-3-nonanoic acid-ethyl ester | 浙江中欣氟材股份有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105777631-A | Synthesizing method of 1-cyclopropyl-4-oxo-7-bromo-8-difluoromethoxy-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester | 浙江中欣氟材股份有限公司 | 2016-07-20 | — | — | CN | disclosed |