Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.42 |
| ▸ | CPT1A | P50416 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30281088 | 0.99 | GPR119 (0.49) | GPR119ARRIPK1SCD5CPT1A | |
| SCHEMBL31421008 | 0.96 | GPR119 (0.51) | GPR119ARRIPK1SCD5NPC1 | |
| SCHEMBL21001077 | 0.92 | GPR119 (0.52) | GPR119ARRIPK1SCD5JAK2 | |
| SCHEMBL30280955 | 0.87 | GPR119 (0.46) | GPR119ARRIPK1SCD5NPC1 | |
| SCHEMBL30280984 | 0.84 | GPR119 (0.47) | GPR119ARJAK2JAK3PTK2 | |
| SCHEMBL30280998 | 0.84 | GPR119 (0.47) | GPR119ARRIPK1JAK2JAK3 | |
| SCHEMBL23646472 | 0.84 | RIPK1 (0.48) | RIPK1NPC1ALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL21611486 | 0.84 | RIPK1 (0.48) | RIPK1NPC1ALDH1A1TMEM97SIGMAR1 | |
| Water SCHEMBL27902502 | 0.84 | RIPK1 (0.62) | GPR119RIPK1ALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL1991706 | 0.83 | RIPK1 (0.47) | RIPK1NPC1ALDH1A1TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177551-B | Heterocyclic modulators of lipid synthesis | 3-V生物科学股份有限公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-105001225-B | The heterocyclic modulators of lipid synthesis | 3-V 生物科学公司 | 2018-04-06 | — | — | CN | disclosed |
| CN-104507928-B | Heterocyclic modulators of lipid synthesis | 3-V生物科学股份有限公司 | 2016-09-28 | — | — | CN | disclosed |