Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethoxycarbonyl Group SCHEMBL27711869 | 0.83 | IDO1 (0.37) | DRD3MTNR1AMTNR1BFFAR1IDO1 | |
| Ethoxycarbonyl Group SCHEMBL28070924 | 0.81 | KDM4E (0.33) | KDM4EALDH1A1GAA | |
| Ethoxycarbonyl Group SCHEMBL28800381 | 0.80 | CYP2A6 (0.39) | DRD3MTNR1AMTNR1BKDM4EALDH1A1 | |
| Ethoxycarbonyl Group SCHEMBL27497693 | 0.77 | TSHR (0.44) | KDM4EALDH1A1NR1D1 | |
| Ethoxycarbonyl Group SCHEMBL28082108 | 0.75 | — | — | |
| Methyl Alcohol SCHEMBL28162178 | 0.74 | IDO1 (0.42) | DRD3MTNR1AMTNR1BIDO1 | |
| SCHEMBL73467 | 0.74 | IDO1 (0.46) | IDO1 | |
| SCHEMBL29728630 | 0.74 | IDO1 (0.46) | IDO1 | |
| Catechol SCHEMBL28070313 | 0.74 | CA2 (0.44) | KDM4EALDH1A1LMNAGAA | |
| Naphthalene SCHEMBL27488215 | 0.73 | ALDH1A1 (0.40) | KDM4EALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105793266-B | Spiro-oxazolones | 豪夫迈·罗氏有限公司 | 2019-02-12 | — | — | CN | disclosed |
| CN-105814062-A | Spiro-oxazolones | 豪夫迈·罗氏有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105793266-A | Spiro-oxazolones | 豪夫迈·罗氏有限公司 | 2016-07-20 | — | — | CN | disclosed |