Flavone

Flavone

SCHEMBL28073133

COC.O=c1cc(-c2ccccc2)oc2ccccc12

nearest known ligand 0.87

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNKS O95271 11/20 0.87
SMN1; SMN2 Q16637 5/20 0.87
HPGD P15428 4/20 0.87
RAB9A P51151 4/20 0.87
PARP1 P09874 4/20 0.87
TNKS2 Q9H2K2 4/20 0.87
NPC1 O15118 3/20 0.87
CYP3A4 P08684 3/20 0.87
ABCB1 P08183 3/20 0.87
TP53 P04637 2/20 0.87
CYP19A1 P11511 2/20 0.87
ABCG2 Q9UNQ0 2/20 0.87
GABRP O00591 2/20 0.87
GABRD O14764 2/20 0.87
GABRA1 P14867 2/20 0.87
GABRB1 P18505 2/20 0.87
GABRG2 P18507 2/20 0.87
GABRB3 P28472 2/20 0.87
GABRA5 P31644 2/20 0.87
GABRA3 P34903 2/20 0.87

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flavone SCHEMBL28248986 0.93 TNKS (1.00) TNKSSMN1; SMN2HPGDRAB9APARP1
Flavone SCHEMBL15676601 0.93 TNKS (1.00) TNKSSMN1; SMN2HPGDRAB9APARP1
Flavone SCHEMBL30542161 0.93 TNKS (1.00) TNKSSMN1; SMN2HPGDRAB9APARP1
Flavone SCHEMBL31316377 0.93 TNKS (1.00) TNKSSMN1; SMN2HPGDRAB9APARP1
Flavone SCHEMBL18879 0.93 TNKS (1.00) TNKSSMN1; SMN2HPGDRAB9APARP1
Flavone SCHEMBL23645524 0.92 TNKS (0.90) TNKSSMN1; SMN2HPGDRAB9APARP1
Flavone SCHEMBL1660769 0.91 TNKS (0.96) TNKSSMN1; SMN2HPGDRAB9APARP1
Flavone SCHEMBL3090011 0.91 TNKS (0.96) TNKSSMN1; SMN2HPGDRAB9APARP1
Flavone SCHEMBL6908621 0.91 TNKS (0.96) TNKSSMN1; SMN2HPGDRAB9APARP1
Flavone SCHEMBL8069086 0.91 TNKS (0.96) TNKSSMN1; SMN2HPGDRAB9APARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105982884-A Application of bavachinin and analogs of bavachinin 上海中医药大学 2016-10-05 CN disclosed