Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Flavone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 known ✓ | P09874 | 4/20 | 0.96 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.96 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.96 |
| ▸ | PARP2 known ✓ | Q9UGN5 | 1/20 | 0.73 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.73 |
| ▸ | TNKS | O95271 | 9/20 | 0.96 |
| ▸ | GABRP | O00591 | 5/20 | 0.96 |
| ▸ | GABRD | O14764 | 5/20 | 0.96 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.96 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.96 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.96 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.96 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.96 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.96 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.96 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.96 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.96 |
| ▸ | GABRE | P78334 | 5/20 | 0.96 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.96 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flavone SCHEMBL28635083 | 0.98 | TNKS (0.93) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL29695444 | 0.98 | TNKS (0.93) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL31316377 | 0.98 | TNKS (1.00) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL30542161 | 0.98 | TNKS (1.00) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL28248986 | 0.98 | TNKS (1.00) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL15676601 | 0.98 | TNKS (1.00) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL18879 | 0.98 | TNKS (1.00) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL3090011 | 0.96 | TNKS (0.96) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL6908621 | 0.96 | TNKS (0.96) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL8069086 | 0.96 | TNKS (0.96) | TNKSGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 184 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-220176116-U | Ginkgo flavone alcohol extraction column in ginkgo leaf | 河北利江生物科技有限公司 | 2023-12-15 | — | — | CN | claimed |
| CN-115161295-A | Enzyme composition capable of converting flavone oxygen glycoside into flavone C glycoside and application thereof | 北京中医药大学 | 2022-10-11 | — | — | CN | claimed |
| CN-114814006-A | Method for measuring chemical component content in agastache rugosus leaves | 天津中医药大学 | 2022-07-29 | — | — | CN | claimed |
| CN-112630339-B | Method for simultaneously and quantitatively measuring 4 blood-entering components in agilawood alcohol extract | 广东省测试分析研究所（中国广州分析测试中心） | 2022-07-26 | — | — | CN | claimed |
| CN-114624367-A | Method for extracting bamboo leaf flavone by solid oxonium salt without solvent under pressure | 四川大学 | 2022-06-14 | — | — | CN | claimed |
| CN-110483629-A | Regulate and control transcription factor, recombinant eukaryon expression vector and the application of the accumulation of plant flowers pigment glycosides | UNIV SOUTH CHINA AGRICULT | 2019-11-22 | — | — | CN | claimed |
| CN-108486136-B | Flavonols 3-O- glucosyltransferase MdUGT71B1 gene and its coding albumen and application | 浙江大学 | 2019-11-15 | — | — | CN | claimed |
| CN-109619336-A | A kind of fruit and vegetable juice processing method inhibiting enzymatic browning | 武汉轻工大学 | 2019-04-16 | — | — | CN | claimed |
| CN-108486136-A | Flavonols 3-O- glucosyltransferase MdUGT71B1 genes and its coding albumen and application | 浙江大学 | 2018-09-04 | — | — | CN | claimed |
| CN-107955067-A | Participate in two myb transcription factors and its application of peach flavonols biosynthetic controlling | 浙江大学 | 2018-04-24 | — | — | CN | claimed |
| CN-104693811-B | Functional gelatin food packaging film and preparation method thereof | 四川大学 | 2017-01-25 | — | — | CN | claimed |
| CN-105837671-A | Flavonol adjusting and controlling protein MsMYB22 obtained from functional apples and coding gene and application thereof | 山东农业大学 | 2016-08-10 | — | — | CN | claimed |
| CN-105744837-A | Use of STING agonists for treating chronic hepatitis b virus infection | 德雷克塞尔大学 | 2016-07-06 | — | — | CN | claimed |
| CN-104693811-A | Functional gelatin food packaging film and preparation method thereof | UNIV SICHUAN | 2015-06-10 | — | — | CN | claimed |
| EP-2490679-A2 | METHODS OF MAKING AND USING COMPOSITIONS COMPRISING FLAVONOIDS | API Genesis, LLC (US) | 2012-08-29 | — | — | EP | claimed |
| US-20120213842-A1 | METHODS OF MAKING AND USING COMPOSITIONS COMPRISING FLAVONOIDS | TPC-API LLC | 2012-08-23 | — | — | US | claimed |
| WO-2011049629-A9 | METHODS OF MAKING AND USING COMPOSITIONS COMPRISING FLAVONOIDS | API GENESIS, LLC (US) | 2012-05-18 | — | — | WO | claimed |
| WO-2011049629-A2 | METHODS OF MAKING AND USING COMPOSITIONS COMPRISING FLAVONOIDS | API GENESIS, LLC (US) | 2011-04-28 | — | — | WO | claimed |
| CN-101292980-B | Pharmaceutical combination containing rapamycin for treating large intestine cancer | RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE | 2010-11-10 | — | — | CN | claimed |
| CN-101292980-A | Pharmaceutical combination containing rapamycin for treating large intestine cancer | RENJI HOSPITAL AFFILIATED TO S (CN) | 2008-10-29 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120213842-A1 | METHODS OF MAKING AND USING COMPOSITIONS COMPRISING FLAVONOIDS | F3, C5, CYP51A1 | PARP1 2981/4885ADORA3 4191/4885DPP4 1766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.