Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273639 | 0.90 | MEN1 (0.48) | MEN1KMT2ANAMPTMAPK1UCHL1 | |
| SCHEMBL11929926 | 0.89 | MTNR1B (0.47) | MEN1KMT2AUCHL1PRMT5WDR77 | |
| SCHEMBL30550841 | 0.87 | MEN1 (0.61) | MEN1KMT2ANAMPTMAPK1UCHL1 | |
| SCHEMBL17001691 | 0.87 | MEN1 (0.61) | MEN1KMT2ANAMPTMAPK1UCHL1 | |
| SCHEMBL19056599 | 0.86 | MEN1 (0.51) | MEN1KMT2ANAMPTMAPK1UCHL1 | |
| SCHEMBL4857225 | 0.85 | MEN1 (0.48) | MEN1KMT2ANAMPTMAPK1OPRD1 | |
| SCHEMBL4858860 | 0.85 | MEN1 (0.50) | MEN1KMT2ANAMPTMAPK1UCHL1 | |
| SCHEMBL11929939 | 0.84 | MEN1 (0.49) | MEN1KMT2ANAMPTMAPK1PRMT5 | |
| SCHEMBL26793670 | 0.82 | MEN1 (0.51) | MEN1KMT2ANAMPTMAPK1UCHL1 | |
| SCHEMBL30581960 | 0.81 | OPRD1 (0.52) | MEN1KMT2ANAMPTMAPK1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814055-B | As the condensed imidazole and pyrazole derivatives of TNF active regulators | UCB生物制药私人有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-105814055-A | Fused imidazole and pyrazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |