Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trichlorfon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.80 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trichlorfon SCHEMBL116996 | 0.89 | LMNA (1.00) | LMNACYP2C19L3MBTL1CYP3A4CYP2C9 | |
| Trichlorfon SCHEMBL6266785 | 0.89 | LMNA (1.00) | LMNACYP2C19L3MBTL1CYP3A4CYP2C9 | |
| Trichlorfon SCHEMBL15972 | 0.89 | LMNA (1.00) | LMNACYP2C19L3MBTL1CYP3A4CYP2C9 | |
| Trichlorfon SCHEMBL27946356 | 0.89 | LMNA (1.00) | LMNACYP2C19L3MBTL1CYP3A4CYP2C9 | |
| Trichlorfon SCHEMBL7032758 | 0.82 | LMNA (0.83) | LMNACYP2C19L3MBTL1CYP3A4CYP2C9 | |
| Trichlorfon SCHEMBL4750566 | 0.82 | LMNA (0.83) | LMNACYP2C19L3MBTL1CYP3A4CYP2C9 | |
| Trichlorfon SCHEMBL8858383 | 0.82 | LMNA (0.83) | LMNACYP2C19L3MBTL1CYP3A4CYP2C9 | |
| Trichlorfon SCHEMBL27797686 | 0.80 | LMNA (0.80) | LMNACYP2C19L3MBTL1CYP3A4CYP2C9 | |
| Trichlorfon SCHEMBL10446443 | 0.78 | LMNA (0.69) | LMNACYP2C19CYP2C9 | |
| Biphenyl SCHEMBL10446339 | 0.74 | LMNA (0.69) | LMNACYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109970760-A | ACC inhibitor and its purposes | 吉利德阿波罗公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-106905346-B | ACC inhibitor and its purposes | 吉利德阿波罗公司 | 2019-05-28 | — | — | CN | disclosed |
| CN-105358143-B | ACC inhibitor and its purposes | 吉利德阿波罗公司 | 2019-01-22 | — | — | CN | disclosed |
| CN-103648277-B | The honeybee repellant of improvement and its application | 尹森特公司 | 2017-07-11 | — | — | CN | disclosed |
| CN-106028808-A | Composition comprising dicamba and a drift control agent comprising at least one fatty alcohol | 巴斯夫欧洲公司 | 2016-10-12 | — | — | CN | disclosed |