Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10498362 | 0.87 | MAPT (0.40) | MAPTKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL6141091 | 0.81 | POLB (0.35) | MAPTKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL10099648 | 0.71 | MAPK1 (0.42) | MAPTKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL6141075 | 0.71 | LMNA (0.37) | KMT2AMEN1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL16151331 | 0.69 | POLB (0.48) | MAPTKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL7593026 | 0.67 | ALDH1A1 (0.60) | MAPTKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL31014788 | 0.64 | ALDH1A1 (0.52) | MAPTKMT2AMEN1L3MBTL1ALDH1A1 | |
| Aethimidinum SCHEMBL29352989 | 0.64 | CASP1 (0.50) | MAPTKMT2ACYP1A2CYP2D6 | |
| SCHEMBL5192452 | 0.62 | NPSR1 (0.50) | MAPTKMT2AMEN1L3MBTL1POLB | |
| SCHEMBL855348 | 0.62 | MAPT (0.68) | MAPTKMT2AMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152675-A1 | TRIAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF CDC25 PHOSPHATASE | IPSEN PHARMA S.A.S. (FR) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008152223-A1 | TRIAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF CDC25 PHOSPHATASE | IPSEN PHARMA S.A.S. (FR) | 2008-12-18 | — | — | WO | disclosed |