Fluorene

Fluorene

SCHEMBL28074807

CC(C)(O)C(C)(C)O.c1ccc2c(c1)Cc1ccccc1-2

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.50
ALDH1A1 P00352 4/20 0.47
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47
KDM4E B2RXH2 1/20 0.47
LMNA P02545 1/20 0.47
MAPT P10636 1/20 0.47
HPGD P15428 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
SRD5A2 P31213 1/20 0.46
CYP1A2 P05177 3/20 0.44
ADRA2A P08913 2/20 0.44
SLC6A2 P23975 2/20 0.44
SLC6A4 P31645 2/20 0.44
HTR2C P28335 2/20 0.44
HTR2B P41595 2/20 0.44
CYP3A4 P08684 1/20 0.43
BCHE P06276 1/20 0.41
CES1 P23141 1/20 0.41
ADRA1A P35348 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluorene SCHEMBL28048590 0.94 MAOA (0.45) MAOAALDH1A1NPC1RAB9AKDM4E
Fluorene SCHEMBL27865340 0.85 MAOA (0.59) MAOAALDH1A1NPC1RAB9AKDM4E
Fluorene SCHEMBL3139239 0.85 MAOA (0.59) MAOAALDH1A1NPC1RAB9AKDM4E
Fluorene SCHEMBL28150649 0.82 MAOA (0.62) MAOAALDH1A1NPC1RAB9AKDM4E
Fluorene SCHEMBL545861 0.82 MAOA (0.68) MAOAALDH1A1NPC1RAB9AKDM4E
Fluorene SCHEMBL29355380 0.82 MAOA (0.68) MAOAALDH1A1NPC1RAB9AKDM4E
Fluorene SCHEMBL31388525 0.82 MAOA (0.68) MAOAALDH1A1NPC1RAB9AKDM4E
Fluorene SCHEMBL8180 0.82 MAOA (0.68) MAOAALDH1A1NPC1RAB9AKDM4E
Fluorene SCHEMBL29478468 0.82 MAOA (0.68) MAOAALDH1A1NPC1RAB9AKDM4E
Fluorene SCHEMBL28872524 0.79 MAOA (0.59) MAOAALDH1A1NPC1RAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105829292-A HETEROCYCLIC SPIRO COMPOUNDS 默克专利有限公司 2016-08-03 CN disclosed