Quinoxaline

Quinoxaline

SCHEMBL28074971

c1c[nH]cn1.c1c[nH]cn1.c1c[nH]cn1.c1c[nH]cn1.c1ccc2nccnc2c1.c1ccncc1.c1cnccn1

nearest known ligand 0.46

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.46
FKBP5 Q13451 1/20 0.46
METAP2 P50579 1/20 0.35
TSHR P16473 1/20 0.32
NAPRT Q6XQN6 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
CCNB2 O95067 3/20 0.32
CDK1 P06493 3/20 0.32
CCNB1 P14635 3/20 0.32
CDK5 Q00535 3/20 0.32
CDK5R1 Q15078 3/20 0.32
CCNB3 Q8WWL7 3/20 0.32
GSK3B P49841 2/20 0.32
GSK3A P49840 1/20 0.32
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31
TGFBR1 P36897 1/20 0.31
MAPK1 P28482 1/20 0.31
NOTUM Q6P988 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinoxaline SCHEMBL83382 0.91 ALDH1A1 (0.56) ALDH1A1FKBP5METAP2TSHRTDP1
Quinoline SCHEMBL28146082 0.85 ALDH1A1 (0.55) ALDH1A1FKBP5TSHR
Imidazole SCHEMBL27749802 0.83 ALDH1A1 (0.56) ALDH1A1FKBP5TSHR
Quinoxaline SCHEMBL28317567 0.81 TSHR (0.38) ALDH1A1METAP2TSHRNAPRTTDP1
Pyridine SCHEMBL27597334 0.80 ALDH1A1 (0.72) ALDH1A1FKBP5TSHRNAPRTTDP1
Pyridine SCHEMBL338772 0.80 ALDH1A1 (0.72) ALDH1A1FKBP5TSHRNAPRTTDP1
Quinoxaline SCHEMBL27565103 0.80 TSHR (0.50) ALDH1A1METAP2TSHRNAPRTTDP1
Pyridine SCHEMBL222252 0.80 ALDH1A1 (0.72) ALDH1A1FKBP5TSHRNAPRTTDP1
Quinoxaline SCHEMBL28053320 0.80 TSHR (0.50) ALDH1A1METAP2TSHRNAPRTTDP1
Pyridine SCHEMBL27834115 0.80 ALDH1A1 (0.72) ALDH1A1FKBP5TSHRNAPRTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105829454-A Dye compounds 默克专利股份有限公司 2016-08-03 CN disclosed