SCHEMBL28075883

SCHEMBL28075883

N[C@H](CCc1ccc(O)cc1Cl)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.47
KMT2A Q03164 2/20 0.47
MEN1 O00255 1/20 0.47
CYP1A2 P05177 1/20 0.47
SLC7A5 Q01650 1/20 0.44
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
HTR1A P08908 1/20 0.43
ADORA3 P0DMS8 1/20 0.43
MAPT P10636 1/20 0.43
ALOX15 P16050 1/20 0.43
TSHR P16473 1/20 0.43
NFKB1 P19838 1/20 0.43
HTR2A P28223 1/20 0.43
HTR2C P28335 1/20 0.43
SLC6A4 P31645 1/20 0.43
HTR7 P34969 1/20 0.43
HTR2B P41595 1/20 0.43
MTOR P42345 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15085673 0.84 KMT2A (0.55) CYP3A4KMT2AMEN1CYP1A2SLC7A5
SCHEMBL5580201 0.84 KMT2A (0.55) CYP3A4KMT2AMEN1CYP1A2SLC7A5
SCHEMBL5580203 0.84 KMT2A (0.55) CYP3A4KMT2AMEN1CYP1A2SLC7A5
SCHEMBL2602021 0.79 SLC6A2 (0.59) SLC7A5SLC6A4GRIA2KIF11GRIK1
SCHEMBL30861811 0.79 SLC6A2 (0.59) SLC7A5SLC6A4GRIA2KIF11GRIK1
SCHEMBL16147380 0.79 SLC6A2 (0.59) SLC7A5SLC6A4GRIA2KIF11GRIK1
SCHEMBL16147379 0.79 SLC6A2 (0.59) SLC7A5SLC6A4GRIA2KIF11GRIK1
Hydrochloric Acid SCHEMBL2117928 0.78 SLC6A2 (0.57) SLC7A5SLC6A4KIF11GRIK1GRIK2
SCHEMBL1702915 0.77 ACLY (0.51) HDAC8
SCHEMBL4208352 0.75 TYR (0.58) CYP3A4KMT2AMEN1MAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110167580-A Pharmaceutical composition and method for treating cancer 迪美公司 2019-08-23 CN claimed
CN-110062633-A Tyrosine derivatives and compositions comprising the same 迪美公司 2019-07-26 CN claimed
CN-105848771-A High-speed centrifugal mixing devices and methods of use 迪美公司 2016-08-10 CN claimed
CN-110167580-A Pharmaceutical composition and method for treating cancer 迪美公司 2019-08-23 CN disclosed
CN-109562116-A Protona and protona derivative and promotor in cancer treatment 迪美公司 2019-04-02 CN disclosed
CN-105848771-A High-speed centrifugal mixing devices and methods of use 迪美公司 2016-08-10 CN disclosed