SCHEMBL4208352

SCHEMBL4208352

Oc1ccc(CCc2ccc(O)cc2Cl)c(Cl)c1

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TYR P14679 3/20 0.58
HSD17B10 Q99714 2/20 0.56
TTR P02766 1/20 0.48
ESR1 P03372 6/20 0.45
ESR2 Q92731 4/20 0.45
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
CA14 Q9ULX7 1/20 0.44
MEN1 O00255 1/20 0.44
MAPT P10636 1/20 0.44
KMT2A Q03164 1/20 0.44
CYP3A4 P08684 1/20 0.42
HPGD P15428 1/20 0.42
CRHBP P24387 1/20 0.42
CRHR2 Q13324 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6165426 0.91 HSD17B10 (0.52) TYRHSD17B10TTRESR1ESR2
SCHEMBL3242232 0.89 ESR1 (0.56) TYRHSD17B10ESR1ESR2CA2
SCHEMBL6577495 0.87 HSD17B10 (0.48) TYRHSD17B10TTRESR1ESR2
SCHEMBL9565680 0.87 TYR (0.50) TYRHSD17B10TTRESR1ESR2
SCHEMBL3767315 0.87 TAAR1 (0.52) TYRHSD17B10ESR1CA12CA1
SCHEMBL16355709 0.86 ALOX5 (0.50) TYRHSD17B10ESR1ESR2HPGD
SCHEMBL6166403 0.85 HSD17B10 (0.56) TYRHSD17B10TTRESR1ESR2
Bromide SCHEMBL4855073 0.85 TAAR1 (0.50) TYRHSD17B10ESR1CA12CA1
SCHEMBL29074533 0.85 HSD17B10 (0.46) TYRHSD17B10TTRESR1ESR2
SCHEMBL11655822 0.83 TYR (0.67) TYRHSD17B10ESR1ESR2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1963433-A2 ANNULAR OR TUBULAR SHAPED ARTICLES OF NOVEL POLYMER BLENDS General Electric Company (US) 2008-09-03 EP claimed
WO-2008091253-A1 HIGH HEAT ELECTRICAL CONNECTORS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-07-31 WO claimed
WO-2008088336-A1 COATED ARTICLES OF MANUFACTURE MADE OF HIGH Tg POLYMER BLENDS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-07-24 WO claimed
EP-1896520-A2 POLYMERIZATION PROCESS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2008-03-12 EP claimed
WO-2007075365-A2 ANNULAR OR TUBULAR SHAPED ARTICLES OF NOVEL POLYMER BLENDS GENERAL ELECTRIC COMPANY (US) 2007-07-05 WO claimed
WO-2006133369-A2 POLYMERIZATION PROCESS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2006-12-14 WO claimed
EP-3386938-A1 METHOD OF BISPHENOL MANUFACTURE SABIC Global Technologies B.V. (NL) 2018-10-17 EP disclosed
EP-3331959-A1 ANIONIC CURABLE COMPOSITIONS Designer Molecules, Inc. (US) 2018-06-13 EP disclosed
WO-2017100164-A1 METHOD OF BISPHENOL MANUFACTURE SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2017-06-15 WO disclosed
WO-2017027482-A1 ANIONIC CURABLE COMPOSITIONS DESIGNER MOLECULES, INC. (US) 2017-02-16 WO disclosed
EP-1984472-B1 POLYCARBONATE COMPOSITIONS AND ARTICLES FORMED THEREFROM SABIC INNOVATIVE PLASTICS IP (NL) 2009-11-18 EP disclosed
EP-2064263-A1 METHOD FOR PRODUCING POLYETHER POLYMERS Sabic Innovative Plastics IP B.V. (NL) 2009-06-03 EP disclosed
EP-1989246-A2 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETHERIMIDES Sabic Innovative Plastics IP B.V. (NL) 2008-11-12 EP disclosed
WO-2007100473-A2 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETHERIMIDES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2007-09-07 WO disclosed
WO-2007078713-A2 HIGH GLASS TRANSITION TEMPERATURE THERMOPLASTIC ARTICLES GENERAL ELECTRIC COMPANY (US) 2007-07-12 WO disclosed
WO-2007075365-A2 ANNULAR OR TUBULAR SHAPED ARTICLES OF NOVEL POLYMER BLENDS GENERAL ELECTRIC COMPANY (US) 2007-07-05 WO disclosed
WO-2006107940-A2 POLYARYLATE COMPOSITIONS AND ARTICLES THEREFROM GENERAL ELECTRIC COMPANY (US) 2006-10-12 WO disclosed
EP-1138719-B1 POLYIMIDE/POLYARYLATE RESIN COMPOSITIONS AND MOLDINGS THEREOF TEIJIN LTD (JP) 2005-02-16 EP disclosed
US-6610794-B1 Excellent heat resistance, moldability, dimensional stability and transparency TEIJIN LIMITED (JP) 2003-08-26 US disclosed
EP-1138719-A1 POLYIMIDE/POLYARYLATE RESIN COMPOSITIONS AND MOLDINGS THEREOF TEIJIN LIMITED (JP) 2001-10-04 EP disclosed