Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | NMUR2 | Q9GZQ4 | 3/20 | 0.45 |
| ▸ | NMUR1 | Q9HB89 | 3/20 | 0.45 |
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.43 |
| ▸ | RAMP3 | O60896 | 3/20 | 0.42 |
| ▸ | CALCR | P30988 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28076142 | 1.00 | KEAP1 (0.48) | KEAP1MAPK8MAPK9MAPK10NMUR2 | |
| SCHEMBL29580287 | 0.87 | CXCR4 (0.45) | NMUR2NMUR1CXCR4OPRM1OPRK1 | |
| SCHEMBL29503109 | 0.85 | EPHA2 (0.44) | NMUR2NMUR1CXCR4OPRM1OPRK1 | |
| SCHEMBL29557983 | 0.85 | OPRM1 (0.49) | NMUR2NMUR1OPRM1OPRK1 | |
| SCHEMBL29608389 | 0.84 | OPRM1 (0.51) | NMUR2NMUR1CXCR4OPRM1OPRK1 | |
| SCHEMBL31380449 | 0.84 | NMUR2 (0.48) | KEAP1MAPK8MAPK9MAPK10NMUR2 | |
| SCHEMBL31481586 | 0.83 | OPRK1 (0.47) | NMUR2NMUR1OPRM1OPRK1 | |
| SCHEMBL31307290 | 0.83 | EP300 (0.53) | KEAP1MAPK8MAPK9MAPK10RAMP3 | |
| SCHEMBL30991505 | 0.83 | KDM1A (0.50) | MAPK8MAPK9MAPK10NMUR2NMUR1 | |
| SCHEMBL30799261 | 0.83 | NMUR2 (0.49) | NMUR2NMUR1CXCR4OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105664173-A | Membrane-permeable short peptide/matrine as well as preparation method and application thereof | 山东省医学科学院药物研究所 | 2016-06-15 | — | — | CN | disclosed |