Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 5/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28703626 | 0.97 | ALDH1A1 (0.43) | ALDH1A1LMNAHSP90AA1CCR6CACNA1B | |
| SCHEMBL7500815 | 0.77 | MAPT (0.37) | ALDH1A1LMNAHSP90AA1CCR6CACNA1B | |
| SCHEMBL157324 | 0.71 | MGLL (0.50) | ALDH1A1LMNAHSP90AA1CCR6APOBEC3G | |
| SCHEMBL15509629 | 0.69 | CHRM2 (0.37) | ALDH1A1LMNA | |
| SCHEMBL27950348 | 0.69 | ALDH1A1 (0.33) | ALDH1A1LMNAHSP90AA1CCR6CACNA1B | |
| SCHEMBL1001751 | 0.65 | POLB (0.50) | ALDH1A1MAPT | |
| SCHEMBL30219773 | 0.65 | KMT2A (0.35) | ALDH1A1LMNAHSP90AA1CCR6CACNA1B | |
| SCHEMBL29643230 | 0.64 | ALDH1A1 (0.49) | ALDH1A1MAPT | |
| SCHEMBL83222 | 0.64 | ALDH1A1 (0.49) | ALDH1A1MAPT | |
| SCHEMBL6193007 | 0.64 | ALDH1A1 (0.49) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105745206-A | Glucose ceramide synthase inhibitors for the treatment of diseases | 生物马林药物股份有限公司 | 2016-07-06 | — | — | CN | disclosed |