Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28703626 | 0.75 | ALDH1A1 (0.43) | TDP1LMNAKMT2AMEN1APAF1 | |
| SCHEMBL13016515 | 0.70 | KDM4E (0.41) | MAPTSMN1; SMN2GAAKDM4ETDP1 | |
| SCHEMBL11110160 | 0.70 | KMT2A (0.47) | MAPTSMN1; SMN2GAATDP1S100A4 | |
| SCHEMBL11661363 | 0.68 | HTR1A (0.43) | MAPTGAAKDM4ETDP1MAPK1 | |
| SCHEMBL24120011 | 0.67 | MGLL (0.48) | MAPTHTTTP53SMN1; SMN2GPR55 | |
| SCHEMBL3795749 | 0.67 | MGLL (0.41) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| SCHEMBL28365598 | 0.67 | ALDH1A1 (0.54) | MAPTHTTTP53SMN1; SMN2GPR55 | |
| SCHEMBL236146 | 0.66 | MGLL (0.47) | TP53SMN1; SMN2KDM4ELMNAKMT2A | |
| SCHEMBL157324 | 0.66 | MGLL (0.50) | MAPTHTTTP53SMN1; SMN2GPR55 | |
| SCHEMBL3436867 | 0.66 | ALDH1A1 (0.69) | MAPTHTTTP53KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871630-B1 | 4a,5a,8a,8b-TETRAHYDRO-6H-PYRROLO 3,4':4,5]FURO(3,2-b)PYRIDINE-6,8 7H]-DIONE DERIVATIVES FOR USE IN CONTROLLING ENDOPARASITES AND A METHOD OF PRODUCING SAID DERIVATIVES | BAYER AG (DE) | 2002-01-02 | — | — | EP | disclosed |
| US-6291472-B1 | 4a, 5a, 8a, 8b-tetrahydro-6H-pyrrolo[3′,4′:4, 5]furo[3,2-b] pyri-dine-6,8(7H)-dione derivatives for control of endoparasites processes for their preparation | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-18 | — | — | US | disclosed |
| US-6110928-A | HUMAN OR VETERINARY MEDICINE | BAYER AKTIENGESELLSCHAFT (DE) | 2000-08-29 | — | — | US | disclosed |
| EP-0871630-A1 | 4a,5a,8a,8b-TETRAHYDRO-6H-PYRROLO 3,4':4,5]FURO(3,2-b)PYRIDINE-6,8 7H]-DIONE DERIVATIVES FOR USE IN CONTROLLING ENDOPARASITES AND A METHOD OF PRODUCING SAID DERIVATIVES | BAYER AG (DE) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997014695-A1 | 4a,5a,8a,8b-TETRAHYDRO-6H-PYRROLO[3,4':4,5]FURO(3,2-b)PYRIDINE-6,8[7H]-DIONE DERIVATIVES FOR USE IN CONTROLLING ENDOPARASITES AND A METHOD OF PRODUCING SAID DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-04-24 | — | — | WO | disclosed |