Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 5/20 | 0.44 |
| ▸ | CHRM3 known ✓ | P20309 | 5/20 | 0.44 |
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.44 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27542895 | 0.80 | APEX1 (0.50) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acrylamide SCHEMBL27612275 | 0.79 | DNM1 (0.46) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acrylamide SCHEMBL1078602 | 0.79 | TSHR (0.46) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL12444967 | 0.78 | — | — | |
| SCHEMBL12906782 | 0.78 | — | — | |
| SCHEMBL12906781 | 0.78 | — | — | |
| SCHEMBL12906788 | 0.78 | — | — | |
| SCHEMBL12906787 | 0.78 | — | — | |
| SCHEMBL12906783 | 0.78 | — | — | |
| SCHEMBL12906789 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658760-A | Well treatment fluids containing a zirconium crosslinker and methods of using the same | 贝克休斯公司 | 2016-06-08 | — | — | CN | disclosed |