Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 11/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzimidazole SCHEMBL11810774 | 0.86 | KDM4E (0.46) | MAPTPOLBTDP1QPCTPRKCI | |
| Benzimidazole SCHEMBL2334176 | 0.83 | PRKCI (0.50) | MAPTTDP1QPCTPRKCIRAB9A | |
| Benzimidazole SCHEMBL28277100 | 0.83 | KDM4E (0.50) | MAPTPOLBTDP1QPCTPRKCI | |
| Benzimidazole SCHEMBL5070094 | 0.82 | KDM4E (0.51) | MAPTPOLBTDP1QPCTPRKCI | |
| Benzimidazole SCHEMBL28800549 | 0.82 | PRKCI (0.46) | MAPTTDP1QPCTPRKCIRAB9A | |
| Benzimidazole SCHEMBL4371075 | 0.82 | KDM4E (0.51) | MAPTPOLBTDP1QPCTPRKCI | |
| Benzimidazole SCHEMBL16583698 | 0.82 | PRKCI (0.46) | MAPTTDP1QPCTPRKCIRAB9A | |
| Benzimidazole SCHEMBL5404384 | 0.81 | PRKCI (0.52) | MAPTTDP1QPCTPRKCIRAB9A | |
| Benzimidazole SCHEMBL6009 | 0.81 | — | — | |
| Benzimidazole SCHEMBL10931770 | 0.81 | SMN1; SMN2 (0.50) | MAPTTDP1QPCTPRKCIRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105753841-B | A kind of N indazoles substituting thioureido analog derivative and its preparation method and application | 西安交通大学 | 2018-01-05 | — | — | CN | disclosed |
| CN-105753841-A | N-indazole substituted thiourea derivatives and preparation method and application thereof | 西安交通大学 | 2016-07-13 | — | — | CN | disclosed |