Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17364020 | 0.82 | ALDH1A1 (0.58) | TDP1SMN1; SMN2ALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL1612968 | 0.82 | ALDH1A1 (0.58) | TDP1SMN1; SMN2ALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL29229957 | 0.80 | TDP1 (0.69) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL29391066 | 0.79 | TDP1 (0.69) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL943484 | 0.79 | TDP1 (0.69) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL18365033 | 0.78 | TDP1 (0.60) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL28424118 | 0.78 | ALDH1A1 (0.56) | TDP1SMN1; SMN2ALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL19006811 | 0.77 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL3842471 | 0.77 | TDP1 (0.58) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL27843148 | 0.77 | TDP1 (0.58) | TDP1TSHRSMN1; SMN2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104812746-B | Bruton's tyrosine kinase inhibitors | 弗·哈夫曼-拉罗切有限公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-105837572-A | N-substituted phenylacrylamide derivative and its preparation method and purpose | 四川大学 | 2016-08-10 | — | — | CN | disclosed |