Sugi Predict

Sugi Predict / Compounds / SCHEMBL943484

SCHEMBL943484

SCHEMBL943484

COc1cccc([N+](=O)[O-])c1C

nearest known ligand 0.69

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 4/20 0.69
▸ ALDH1A1 P00352 2/20 0.69
▸ L3MBTL1 Q9Y468 2/20 0.61
▸ TSHR P16473 3/20 0.60
▸ SMN1; SMN2 Q16637 3/20 0.60
▸ KMT2A Q03164 4/20 0.51
▸ MEN1 O00255 3/20 0.51
▸ GAA P10253 2/20 0.51
▸ MAPT P10636 2/20 0.49
▸ KDM4E B2RXH2 2/20 0.49
▸ LMNA P02545 2/20 0.49
▸ ALOX12 P18054 1/20 0.49
▸ MAPK1 P28482 1/20 0.49
▸ HSD17B10 Q99714 1/20 0.48
▸ NPC1 O15118 2/20 0.47
▸ RAB9A P51151 2/20 0.47
▸ RECQL P46063 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29391066 1.00 TDP1 (0.69) TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2
SCHEMBL5159608 0.90 TDP1 (0.57) TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2
SCHEMBL29229957 0.86 TDP1 (0.69) TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2
SCHEMBL19006811 0.83 TDP1 (0.64) TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2
SCHEMBL31077739 0.82 ALDH1A1 (0.55) TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2
SCHEMBL2088309 0.82 TDP1 (0.71) TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2
SCHEMBL7159716 0.82 ALDH1A1 (0.71) TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2
SCHEMBL1161927 0.82 TDP1 (0.71) TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2
SCHEMBL31119224 0.82 TDP1 (0.71) TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2
SCHEMBL31119225 0.82 TDP1 (0.71) TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 285 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1680131-A4 SUBSTITUTED INDOLE-O-GLUCOSIDES JANSSEN PHARMACEUTICA NV (BE) 2009-05-27 — — EP claimed
US-20090105164-A1 SUBSTITUTED INDOLE-O-GLUCOSIDES BEAVERS MARY PAT 2009-04-23 — — US claimed
US-7129220-B2 Substituted indole-O-glucosides JANSSEN PHARMACEUTICA N.V (BE) 2006-10-31 — — US claimed
EP-1680131-A2 SUBSTITUTED INDOLE-O-GLUCOSIDES JANSSEN PHARMACEUTICA N.V. (BE) 2006-07-19 — — EP claimed
US-20050037981-A1 Substituted indole-O-glucosides JANSSEN PHARMACEUTICA N.V. (BE) 2005-02-17 — — US claimed
WO-2005012243-A2 SUBSTITUTED INDOLE-O-GLUCOSIDES JANSSEN PHARMACEUTICA N.V. (BE) 2005-02-10 — — WO claimed
JP-59164786-A — — None — — JP disclosed
EP-4713313-A2 TETRAHYDRONAPTHYRIDINE AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD Springworks Therapeutics, Inc. (US) 2026-03-25 — — EP disclosed
EP-4709712-A1 GSK3A INHIBITORS AND METHODS OF USE THEREOF Blueprint Medicines Corporation (US) 2026-03-18 — — EP disclosed
US-12384751-B2 Allosteric activators of the ALPHA1A-adrenergic receptor THE CLEVELAND CLINIC FOUNDATION (US) 2025-08-12 — — US disclosed
US-20240417398-A1 TETRAHYDRONAPTHYRIDINE AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD SPRINGWORKS THERAPEUTICS, INC. 2024-12-19 — — US disclosed
WO-2024238763-A2 TETRAHYDRONAPTHYRIDINE AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD SPRINGWORKS THERAPEUTICS, INC. (US) 2024-11-21 — — WO disclosed
WO-2024233900-A1 GSK3A INHIBITORS AND METHODS OF USE THEREOF BLUEPRINT MEDICINES CORPORATION (US) 2024-11-14 — — WO disclosed
US-4214003-A ANTIINFLAMMATORY AGENTS WILLIAM H. RORER, INC. (US) 1980-07-22 — — US disclosed
US-4197314-A WITH A DIPHENYL NITRONE WILLIAM H. RORER, INC. (US) 1980-04-08 — — US disclosed
US-4153722-A ANTIINFLAMMATORY, A-PHENYL-N-PHENYLNITRONE WILLIAM H. RORER, INC. (US) 1979-05-08 — — US disclosed
US-4013664-A PSCHORR CYCLIZATION RESEARCH CORPORATION (US) 1977-03-22 — — US disclosed
US-3973947-A 1,3,5-Triazinediones and their use as selective herbicides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-08-10 — — US disclosed
US-3963698-A Alkylations employing in situ generation of diazoalkane alkylation reagents MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1976-06-15 — — US disclosed
US-3951971-A SELECTIVE HERBICIDES FUCHS JULIUS JAKOB 1976-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12384751-B2 Allosteric activators of the ALPHA1A-adrenergic receptor ADRA1A, ADRB1, ADRA1D TDP1 987/4885ALDH1A1 145/4885L3MBTL1 1740/4885
US-20090105164-A1 SUBSTITUTED INDOLE-O-GLUCOSIDES GPR119, PYGL, IAPP TDP1 2022/4885ALDH1A1 2682/4885L3MBTL1 3199/4885
US-20240417398-A1 TETRAHYDRONAPTHYRIDINE AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD YAP1, TEAD2, TEAD1 TDP1 680/4885ALDH1A1 3016/4885L3MBTL1 733/4885
US-20050037981-A1 Substituted indole-O-glucosides GPR119, PYGL, IAPP TDP1 2022/4885ALDH1A1 2682/4885L3MBTL1 3199/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.