Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23421580 | 0.85 | TDP1 (0.56) | TDP1TSHRALDH1A1SMN1; SMN2GAA | |
| SCHEMBL471777 | 0.84 | ALDH1A1 (0.61) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL30520310 | 0.84 | ALDH1A1 (0.61) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL17005575 | 0.83 | TSHR (0.51) | TDP1TSHRALDH1A1SMN1; SMN2GAA | |
| SCHEMBL27372762 | 0.83 | ALDH1A1 (0.59) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL25329772 | 0.83 | ALDH1A1 (0.59) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL10499773 | 0.82 | ALDH1A1 (0.46) | TDP1TSHRALDH1A1SMN1; SMN2GAA | |
| SCHEMBL25331485 | 0.82 | TSHR (0.50) | TDP1TSHRALDH1A1SMN1; SMN2GAA | |
| SCHEMBL29229957 | 0.80 | TDP1 (0.69) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL23420829 | 0.80 | TDP1 (0.50) | TDP1TSHRALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619095-B2 | Process for the preparation of indolone derivative | ALEMBIC LIMITED (IN) | 2009-11-17 | — | — | US | claimed |
| EP-1848691-B1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | ALEMBIC LTD (IN) | 2009-11-11 | — | — | EP | claimed |
| US-20080262244-A1 | Process for the Preparation of Indolone Derivative | ALEMBIC LIMITED (IN) | 2008-10-23 | — | — | US | claimed |
| EP-1848691-A1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | Alembic Limited (IN) | 2007-10-31 | — | — | EP | claimed |
| WO-2006123356-A1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | ALEMBIC LIMITED (IN) | 2006-11-23 | — | — | WO | claimed |
| US-7619095-B2 | Process for the preparation of indolone derivative | ALEMBIC LIMITED (IN) | 2009-11-17 | — | — | US | disclosed |
| EP-1848691-B1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | ALEMBIC LTD (IN) | 2009-11-11 | — | — | EP | disclosed |
| EP-1706113-B1 | A PROCESS FOR THE PREPARATION OF 4-(2-DIPROPYLAMINOETHYL)-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE | USV LTD (IN) | 2008-12-10 | — | — | EP | disclosed |
| US-20080262244-A1 | Process for the Preparation of Indolone Derivative | ALEMBIC LIMITED (IN) | 2008-10-23 | — | — | US | disclosed |
| US-7378439-B2 | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride | USV, LTD. (IN) | 2008-05-27 | — | — | US | disclosed |
| EP-1848691-A1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | Alembic Limited (IN) | 2007-10-31 | — | — | EP | disclosed |
| CN-1968952-A | New indazole and indolone derivatives and their use pharmaceuticals | PFIZER (US) | 2007-05-23 | — | — | CN | disclosed |
| WO-2006123356-A1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | ALEMBIC LIMITED (IN) | 2006-11-23 | — | — | WO | disclosed |
| EP-1706113-A1 | A PROCESS FOR THE PREPARATION OF 4-(2-DIPROPYLAMINOETHYL)-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE | USV Limited (IN) | 2006-10-04 | — | — | EP | disclosed |
| CN-1264838-C | Indole derivatives for treating central nervous system disease | LUNDBECK & CO AS H (DK) | 2006-07-19 | — | — | CN | disclosed |
| US-20050192338-A1 | Process for the preparation of Ropinirole | CF PHARMA GYOGYSZERGYARTO KFT. (HU) | 2005-09-01 | — | — | US | disclosed |
| EP-1568689-A1 | Process for the preparation of the 2-oxoindole derivative, Ropinirole | Helm AG (DE) | 2005-08-31 | — | — | EP | disclosed |
| WO-2005067922-A1 | A PROCESS FOR THE PREPARATION OF 4-(2-DIPROPYLAMINOETHYL)-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE | USV LIMITED (IN) | 2005-07-28 | — | — | WO | disclosed |
| US-20050159605-A1 | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride | USV LIMITED (IN) | 2005-07-21 | — | — | US | disclosed |
| CN-1451002-A | Indole derivatives for treating central nervous system disease | LUNDBECK & CO AS H (DK) | 2003-10-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159605-A1 | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride | PARK7, SNCA, TPH1 | TDP1 191/4885TSHR 1729/4885ALDH1A1 351/4885 |
| US-20080262244-A1 | Process for the Preparation of Indolone Derivative | HTR3C, HTR3B, HTR1B | TDP1 1934/4885TSHR 443/4885ALDH1A1 786/4885 |
| US-20050192338-A1 | Process for the preparation of Ropinirole | PRLHR, ADCYAP1R1, QDPR | TDP1 1853/4885TSHR 280/4885ALDH1A1 1633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.