Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 5/20 | 0.59 |
| ▸ | HMGCR | P04035 | 5/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL874695 | 0.98 | PTPN7 (0.61) | PTPN7HMGCRTDP1RECQLMEN1 | |
| Bicarbonate SCHEMBL30656137 | 0.98 | PTPN7 (0.61) | PTPN7HMGCRTDP1RECQLMEN1 | |
| Bicarbonate SCHEMBL873829 | 0.96 | HMGCR (0.57) | PTPN7HMGCRTDP1RECQLMEN1 | |
| Acetic Acid SCHEMBL28886472 | 0.89 | HMGCR (0.55) | PTPN7HMGCRTDP1RECQLMEN1 | |
| Bicarbonate SCHEMBL28984116 | 0.89 | HMGCR (0.50) | PTPN7HMGCRTDP1RECQLMEN1 | |
| Bicarbonate SCHEMBL15967903 | 0.86 | PTPN7 (0.75) | PTPN7HMGCRTDP1RECQLMEN1 | |
| Bicarbonate SCHEMBL15967786 | 0.86 | PTPN7 (0.75) | PTPN7HMGCRTDP1RECQLMEN1 | |
| Bicarbonate SCHEMBL15967688 | 0.86 | PTPN7 (0.75) | PTPN7HMGCRTDP1RECQLMEN1 | |
| SCHEMBL9015838 | 0.86 | PTPN7 (0.48) | PTPN7HMGCRTDP1RECQLMEN1 | |
| SCHEMBL54883 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105633345-A | Nonaqueous electrolyte solution for secondary battery and nonaqueous electrolyte secondary battery using same | MITSUBISHI CHEM CORP | 2016-06-01 | — | — | CN | disclosed |