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SCHEMBL28079095

SCHEMBL28079095

Cc1cc(C)c(S(=O)(=O)N2CCC(CC3CCN(Cl)CC3)CC2)c(C)c1

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ EBP Q15125 5/20 0.57
▸ DHCR7 Q9UBM7 5/20 0.57
▸ NPSR1 Q6W5P4 1/20 0.55
▸ EPHX2 P34913 10/20 0.52
▸ ALDH1A1 P00352 1/20 0.51
▸ MEN1 O00255 1/20 0.49
▸ MAPK1 P28482 1/20 0.49
▸ KMT2A Q03164 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7925677 0.81 EBP (0.61) EBPDHCR7NPSR1EPHX2ALDH1A1
SCHEMBL22032774 0.81 ALDH1A1 (0.62) EBPDHCR7NPSR1EPHX2ALDH1A1
SCHEMBL22032742 0.78 ALDH1A1 (0.63) EBPDHCR7NPSR1EPHX2ALDH1A1
SCHEMBL5963420 0.76 EPHX2 (0.60) EBPDHCR7NPSR1EPHX2ALDH1A1
SCHEMBL10019221 0.75 EPHX2 (0.64) EBPDHCR7EPHX2
SCHEMBL22033930 0.75 EBP (0.67) EBPDHCR7NPSR1EPHX2ALDH1A1
SCHEMBL31212435 0.75 EBP (0.70) EBPDHCR7NPSR1EPHX2ALDH1A1
SCHEMBL31212431 0.75 EBP (0.70) EBPDHCR7NPSR1EPHX2ALDH1A1
SCHEMBL22032760 0.75 EBP (0.61) EBPDHCR7NPSR1EPHX2ALDH1A1
SCHEMBL20306068 0.75 EBP (0.61) EBPDHCR7NPSR1EPHX2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105873913-A Therapeutics targeting truncated adenomatous polyposis coli (APC) proteins 得克萨斯系统大学评议会 2016-08-17 — — CN disclosed