Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.60 |
| ▸ | EBP | Q15125 | 5/20 | 0.56 |
| ▸ | DHCR7 | Q9UBM7 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7925677 | 0.80 | EBP (0.61) | EPHX2EBPDHCR7KMT2ANPSR1 | |
| SCHEMBL22032774 | 0.80 | ALDH1A1 (0.62) | EPHX2EBPDHCR7KMT2ANPSR1 | |
| SCHEMBL22032742 | 0.77 | ALDH1A1 (0.63) | EPHX2EBPDHCR7KMT2ANPSR1 | |
| SCHEMBL22033858 | 0.77 | EPHX2 (0.62) | EPHX2EBPDHCR7NPSR1ALDH1A1 | |
| SCHEMBL22032778 | 0.76 | EBP (0.69) | EPHX2EBPDHCR7KMT2ANPSR1 | |
| SCHEMBL28079095 | 0.76 | EBP (0.57) | EPHX2EBPDHCR7KMT2ANPSR1 | |
| SCHEMBL10019216 | 0.75 | EPHX2 (1.00) | EPHX2 | |
| SCHEMBL5362423 | 0.74 | EPHX2 (0.62) | EPHX2 | |
| SCHEMBL22033211 | 0.74 | EPHX2 (0.68) | EPHX2EBPDHCR7NPSR1 | |
| SCHEMBL4746087 | 0.74 | KMT2A (0.53) | KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094808-B2 | Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2006-08-22 | — | — | US | disclosed |
| US-20030100615-A1 | Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment | BERGERON RAYMOND J (US) | 2003-05-29 | — | — | US | disclosed |
| US-20020143068-A1 | Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment | BERGERON RAYMOND J (US) | 2002-10-03 | — | — | US | disclosed |
| US-6342534-B1 | BRIDGING GROUPS MAINTAIN DISTANCE BETWEEN NITROGEN ATOMS BINDING VIA ELECTROSTATIC INTERACTION TO COUNTER-ANIONS; ANTITUMOR,ANTICARCINOGENIC AGENTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2002-01-29 | — | — | US | disclosed |
| US-5886051-A | MODULATORS OF THE N-METHYLASPARTIC ACID RECEPTOR; AGONISTS AND ANTAGONISTS; ALZHEIMER'S DISEASE; COGNITION ACTIVATORS; ACYCLIC AND CYCLIC COMPOUNDS HAVING TWO OR MORE SECONDARY AMINES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 1999-03-23 | — | — | US | disclosed |
| US-5843959-A | Methods and bicyclic polyamine compositions for the treatment of inflammation | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 1998-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100615-A1 | Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment | SLC7A1, SRM, SLC1A5 | EPHX2 3990/4885EBP 939/4885DHCR7 3465/4885 |
| US-20020143068-A1 | Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment | SLC7A1, SRM, SLC1A5 | EPHX2 3990/4885EBP 939/4885DHCR7 3465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.