Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 4/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.32 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27866256 | 0.89 | MAP2K4 (0.38) | MAP2K4PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL28835241 | 0.80 | FADS1 (0.40) | MAP2K4LMNA | |
| SCHEMBL28272283 | 0.80 | ROCK2 (0.35) | MAP2K4NTRK1DYRK1ALMNARAB9A | |
| SCHEMBL28809977 | 0.76 | KDM4E (0.43) | IDO1CNR2CNR1RAB9AMAPK10 | |
| SCHEMBL28258471 | 0.73 | NTRK1 (0.43) | MAP2K4PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL28079288 | 0.71 | NTRK1 (0.45) | MAP2K4PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL616627 | 0.70 | ICAM1 (0.38) | MAP2K4MAPK1RAB9A | |
| SCHEMBL28273810 | 0.70 | MTNR1A (0.34) | DYRK1ASMN1; SMN2 | |
| SCHEMBL27623660 | 0.69 | PDPK1 (0.46) | FGFR1PRKAA1NTRK1CLK2DYRK1A | |
| SCHEMBL24424194 | 0.69 | MAP2K4 (0.49) | MAP2K4FGFR1PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658640-A | Alkynyl alcohols and methods of use | 豪夫迈·罗氏有限公司 | 2016-06-08 | — | — | CN | disclosed |