Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 4/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.47 |
| ▸ | CLK3 | P49761 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | WNT1 | P04628 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.44 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13554360 | 0.86 | JAK2 (0.50) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL12339927 | 0.81 | GSK3B (0.49) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL16517211 | 0.81 | KDM4E (0.60) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL28258471 | 0.80 | NTRK1 (0.43) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL23368472 | 0.80 | GSK3B (0.47) | PRKAG1PRKAA1PRKAB1CLK2CLK3 | |
| SCHEMBL28079206 | 0.79 | DYRK1A (0.69) | CLK2CLK3DYRK1AWNT1GSK3B | |
| SCHEMBL8877161 | 0.79 | JAK2 (0.54) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL15942818 | 0.78 | MAP2K4 (0.62) | PRKAG1PRKAA1PRKAB1CLK2CLK3 | |
| SCHEMBL17039120 | 0.78 | JAK2 (0.64) | PRKAG1PRKAA1PRKAB1CLK2CLK3 | |
| SCHEMBL6195016 | 0.78 | DYRK1A (0.44) | PRKAG1PRKAA1PRKAB1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658640-A | Alkynyl alcohols and methods of use | 豪夫迈·罗氏有限公司 | 2016-06-08 | — | — | CN | disclosed |