Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.54 |
| ▸ | JAK1 | P23458 | 2/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.42 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877902 | 0.86 | JAK1 (0.65) | JAK2JAK1TYK2JAK3PRKAG1 | |
| SCHEMBL23368472 | 0.84 | GSK3B (0.47) | JAK2JAK1TYK2JAK3NTRK1 | |
| SCHEMBL1963463 | 0.84 | PRKAG1 (0.56) | PRKAG1PRKAA1PRKAB1PDPK1HSP90AB1 | |
| SCHEMBL17039120 | 0.81 | JAK2 (0.64) | JAK2JAK1TYK2JAK3NTRK1 | |
| SCHEMBL16246796 | 0.81 | JAK2 (0.48) | JAK2JAK1NTRK1WNT1CLK2 | |
| SCHEMBL6195016 | 0.81 | DYRK1A (0.44) | JAK2JAK1TYK2JAK3NTRK1 | |
| SCHEMBL15942818 | 0.81 | MAP2K4 (0.62) | JAK2JAK1TYK2JAK3NTRK1 | |
| SCHEMBL28575862 | 0.81 | NTRK1 (0.58) | NTRK1WNT1CLK2CLK3DYRK1A | |
| SCHEMBL2671620 | 0.80 | JAK2 (0.49) | JAK2JAK1NTRK1WNT1CLK2 | |
| SCHEMBL10130802 | 0.80 | JAK2 (0.60) | JAK2JAK1TYK2JAK3MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336128-A1 | Benzoisothiazoles and preparation and uses thereof | Memory Pharmaceuticals Corporation (US) | 2011-06-22 | — | — | EP | disclosed |
| US-5684003-A | GASTROINTESTINAL DISORDERS OR ANTIULCER AGENTS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-11-04 | — | — | US | disclosed |