Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 6/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953396 | 0.85 | PRKAG1 (0.55) | PRKAG1PRKAA1PRKAB1HAO1 | |
| SCHEMBL23368472 | 0.83 | GSK3B (0.47) | DYRK1ANTRK1WNT1CLK2CLK3 | |
| SCHEMBL8877161 | 0.81 | JAK2 (0.54) | DYRK1ANTRK1WNT1CLK2CLK3 | |
| SCHEMBL17039120 | 0.80 | JAK2 (0.64) | DYRK1ANTRK1WNT1CLK2CLK3 | |
| SCHEMBL28575862 | 0.80 | NTRK1 (0.58) | DYRK1ANTRK1WNT1CLK2CLK3 | |
| SCHEMBL16246796 | 0.80 | JAK2 (0.48) | DYRK1ANTRK1WNT1CLK2CLK3 | |
| SCHEMBL15942818 | 0.80 | MAP2K4 (0.62) | DYRK1ANTRK1WNT1CLK2CLK3 | |
| SCHEMBL1141823 | 0.80 | KDM4E (0.63) | DYRK1ANTRK1CLK2PRKAG1PRKAA1 | |
| SCHEMBL4295771 | 0.80 | CDC7 (0.47) | DYRK1AWNT1CLK2CLK3MAPK1 | |
| SCHEMBL19001429 | 0.80 | YTHDC1 (0.63) | DYRK1ANTRK1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534685-A1 | 1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS CYCLIN DEPENDENT KINASES (CDK) INHIBITORS | Astex Technology Limited (GB) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004014864-A1 | 1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS CYCLIN DEPENDENT KINASES (CDK) INHIBITORS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-02-19 | — | — | WO | disclosed |