Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3107530 | 0.86 | MAPT (0.52) | LMNAPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL16065199 | 0.83 | MAPT (0.59) | LMNAPOLBALDH1A1SMN1; SMN2PRMT5 | |
| SCHEMBL1468345 | 0.83 | LMNA (0.59) | LMNAPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL3406144 | 0.83 | ALDH1A1 (0.70) | LMNAPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL28102683 | 0.83 | MEN1 (0.66) | LMNAPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL9725101 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2L3MBTL1HTTCA2 | |
| SCHEMBL9361525 | 0.81 | LMNA (0.57) | LMNAPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL16016884 | 0.80 | LMNA (0.56) | LMNAPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL17761132 | 0.80 | LMNA (0.56) | LMNAPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL15209559 | 0.80 | LMNA (0.56) | LMNAPOLBALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105801582-A | Novel dihydro pteridinone derivative, preparing method thereof and application to medicine | 合肥工业大学 | 2016-07-27 | — | — | CN | disclosed |