Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.65 |
| ▸ | AURKA | O14965 | 4/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.50 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4584445 | 0.86 | MAPT (0.55) | RPS6KB1AURKAKCNH2SYKPARP1 | |
| Hydrochloric Acid SCHEMBL22609596 | 0.84 | MAPT (0.54) | RPS6KB1AURKAKCNH2SYKPARP1 | |
| SCHEMBL17961844 | 0.83 | RPS6KB1 (0.50) | RPS6KB1AURKACHEK1KCNH2SYK | |
| SCHEMBL17961842 | 0.83 | RPS6KB1 (0.50) | RPS6KB1AURKACHEK1KCNH2SYK | |
| SCHEMBL3718998 | 0.83 | MAPT (0.52) | RPS6KB1AURKAKCNH2SYKMAPT | |
| SCHEMBL2718370 | 0.83 | SYK (0.53) | RPS6KB1AURKASYKMAPTHTT | |
| SCHEMBL28282980 | 0.81 | MAPK8 (0.52) | RPS6KB1AURKASYKMAPTHTT | |
| SCHEMBL3638560 | 0.80 | MAPK1 (0.50) | RPS6KB1AURKAKCNH2SYKMAPK1 | |
| SCHEMBL665801 | 0.79 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKBPDPK1 | |
| Hydrochloric Acid SCHEMBL26614385 | 0.79 | RPS6KB1 (0.48) | RPS6KB1AURKACHEK1KCNH2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061967-B | The nicotinamide compounds replaced through heteroaryl | 百时美施贵宝公司 | 2019-04-19 | — | — | CN | claimed |
| CN-105793248-B | Phthalazinone derivatives and process for preparing the same | 日东制药株式会社 | 2019-08-16 | — | — | CN | disclosed |
| CN-105793248-A | Novel phthalazinone derivatives and process for preparing the same | 日东制药株式会社 | 2016-07-20 | — | — | CN | disclosed |