Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28382631 | 0.79 | ATM (0.42) | GAAALDH1A1MAPTHSP90AB1L3MBTL1 | |
| SCHEMBL7584988 | 0.79 | MAOB (0.38) | ALDH1A1HPGDMAOBMAPK1 | |
| SCHEMBL10388340 | 0.78 | ALDH1A1 (0.38) | GAAALDH1A1MAPTHSP90AB1L3MBTL1 | |
| SCHEMBL27952340 | 0.78 | TRPM8 (0.35) | GAAALDH1A1MAPTHSP90AB1L3MBTL1 | |
| SCHEMBL10388490 | 0.76 | PARP1 (0.45) | GAAL3MBTL1HPGDKMT2AMEN1 | |
| SCHEMBL4023724 | 0.76 | KDM4E (0.39) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28294101 | 0.76 | NR4A2 (0.41) | GAAALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL3461270 | 0.74 | CREBBP (0.41) | L3MBTL1LMNAHPGDSMN1; SMN2RXFP1 | |
| SCHEMBL7574364 | 0.74 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNAHPGDKMT2A | |
| SCHEMBL26613848 | 0.72 | HDAC3 (0.37) | GAAALDH1A1MAPTHSP90AB1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814022-B | Condensed bicyclic heteroaromatic derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-105814022-A | Fused bicyclic heteroaromatic derivatives as modulators of tnf activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |