Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27410635 | 0.81 | L3MBTL1 (0.43) | L3MBTL1KMT2APOLBCYP4F2CYP4A11 | |
| SCHEMBL2512047 | 0.80 | CYP3A4 (0.49) | CYP4F2CYP4A11KDM4EALDH1A1HTT | |
| SCHEMBL5129422 | 0.79 | FFAR1 (0.39) | KMT2ACYP1A2HTTNPSR1 | |
| SCHEMBL4317205 | 0.79 | FFAR1 (0.39) | KMT2ACYP1A2HTTNPSR1 | |
| SCHEMBL4310166 | 0.77 | HTT (0.40) | L3MBTL1KMT2AALOX15CYP1A2HTT | |
| SCHEMBL10686670 | 0.75 | SMN1; SMN2 (0.44) | L3MBTL1KMT2APOLBCYP4F2CYP4A11 | |
| SCHEMBL16796703 | 0.75 | NLRP3 (0.46) | L3MBTL1KMT2APOLBCYP4F2CYP4A11 | |
| SCHEMBL28266226 | 0.74 | HTT (0.37) | ALDH1A1HTTNPSR1 | |
| SCHEMBL4902813 | 0.73 | L3MBTL1 (0.37) | L3MBTL1KMT2APOLBCYP4F2CYP4A11 | |
| SCHEMBL7361591 | 0.73 | PDCD1 (0.48) | ALOX15NLRP3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814048-B | Fused tricyclic benzimidizole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105814048-A | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |