Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.34 |
| ▸ | MEN1 | O00255 | 8/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28080254 | 0.81 | MAPT (0.50) | HPGDMAPTHTTKMT2AMEN1 | |
| SCHEMBL22450458 | 0.81 | MAPT (0.50) | HPGDMAPTHTTKMT2AMEN1 | |
| SCHEMBL19634050 | 0.79 | KDM4E (0.41) | HPGDTSHRMAPTKMT2AMEN1 | |
| SCHEMBL16796947 | 0.76 | TSHR (0.38) | HPGDTSHRMAPTCCR5HTT | |
| SCHEMBL16796949 | 0.76 | TSHR (0.38) | HPGDTSHRMAPTCCR5HTT | |
| SCHEMBL28266838 | 0.74 | ALDH1A1 (0.38) | MAPTHTTKMT2AMEN1GAA | |
| SCHEMBL12352378 | 0.73 | KMT2A (0.40) | HPGDTSHRMAPTHTTKMT2A | |
| SCHEMBL30480709 | 0.72 | ERN1 (0.47) | HPGDTSHRMAPTHTTKMT2A | |
| SCHEMBL16954082 | 0.72 | TSHR (0.41) | HPGDTSHRMAPTCCR5HTT | |
| SCHEMBL613846 | 0.72 | ERN1 (0.47) | HPGDTSHRMAPTHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814048-B | Fused tricyclic benzimidizole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105814048-A | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |