Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22450458 | 1.00 | MAPT (0.50) | MAPTSMN1; SMN2GAAL3MBTL1MEN1 | |
| SCHEMBL28080217 | 0.81 | HPGD (0.40) | MAPTSMN1; SMN2GAAL3MBTL1MEN1 | |
| SCHEMBL28266838 | 0.77 | ALDH1A1 (0.38) | MAPTSMN1; SMN2GAAL3MBTL1MEN1 | |
| SCHEMBL27407257 | 0.77 | MEN1 (0.39) | MAPTSMN1; SMN2GAAL3MBTL1MEN1 | |
| SCHEMBL27407295 | 0.77 | MEN1 (0.39) | MAPTSMN1; SMN2GAAL3MBTL1MEN1 | |
| SCHEMBL5807443 | 0.75 | L3MBTL1 (0.56) | MAPTSMN1; SMN2GAAL3MBTL1MEN1 | |
| SCHEMBL5807441 | 0.75 | L3MBTL1 (0.56) | MAPTSMN1; SMN2GAAL3MBTL1MEN1 | |
| SCHEMBL5806577 | 0.74 | L3MBTL1 (0.51) | MAPTSMN1; SMN2GAAL3MBTL1MEN1 | |
| SCHEMBL5806575 | 0.74 | L3MBTL1 (0.51) | MAPTSMN1; SMN2GAAL3MBTL1MEN1 | |
| SCHEMBL28241514 | 0.74 | HPGD (0.56) | MAPTSMN1; SMN2GAAL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137609-A | The cyclic compound of conditioning agent as TNF α | 百时美施贵宝公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-105814048-B | Fused tricyclic benzimidizole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105814048-A | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |