SCHEMBL28080973

SCHEMBL28080973

O=C1C(c2ccccc2)=C(c2ccccc2)C(=O)N1Cc1ccc(OCc2ccccc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 3/20 0.54
NR1H3 Q13133 3/20 0.54
ENPP2 Q13822 2/20 0.53
GSTP1 P09211 2/20 0.52
PTPN1 P18031 4/20 0.51
NPC1 O15118 2/20 0.49
TP53 P04637 2/20 0.49
HRH3 Q9Y5N1 1/20 0.49
S1PR5 Q9H228 1/20 0.49
RAB9A P51151 1/20 0.49
KDM4E B2RXH2 1/20 0.49
MEN1 O00255 1/20 0.49
ALDH1A1 P00352 1/20 0.49
KMT2A Q03164 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
PTPRF P10586 1/20 0.48
PTPN2 P17706 1/20 0.48
PTPRB P23467 1/20 0.48
ACP1 P24666 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1680623 0.85 CASP3 (0.61) ENPP2GSTP1PTPN1S1PR5NPSR1
SCHEMBL31666963 0.85 CASP3 (0.61) ENPP2GSTP1PTPN1S1PR5NPSR1
SCHEMBL15437828 0.84 NR1H2 (0.70) NR1H2NR1H3MEN1ALDH1A1KMT2A
SCHEMBL28080906 0.82 NR1H2 (0.71) NR1H2NR1H3KDM4EMEN1KMT2A
SCHEMBL30320663 0.79 NR1H2 (0.71) NR1H2NR1H3NPC1RAB9AKDM4E
SCHEMBL28080839 0.78 NR1H2 (0.68) NR1H2NR1H3TP53MEN1ALDH1A1
SCHEMBL15437830 0.76 CASP3 (0.59) NR1H2NR1H3MEN1ALDH1A1KMT2A
SCHEMBL31667726 0.76 POLB (0.50) ENPP2GSTP1HRH3MEN1KMT2A
SCHEMBL31667505 0.76 ALDH1A1 (0.52) ENPP2GSTP1S1PR5MEN1ALDH1A1
SCHEMBL28831871 0.76 NR1H2 (0.52) NR1H2NR1H3KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103804108-B A kind of method preparing primary amine 沈阳药科大学 2016-08-03 CN disclosed