Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL3843888 | 0.97 | CA5A (0.40) | CA5ACA5BMAPTSMN1; SMN2KDM4E | |
| Trolamine SCHEMBL248272 | 0.97 | CA5A (0.40) | CA5ACA5BMAPTSMN1; SMN2KDM4E | |
| Trolamine SCHEMBL4654746 | 0.97 | CA5A (0.40) | CA5ACA5BMAPTSMN1; SMN2KDM4E | |
| Trolamine SCHEMBL8619061 | 0.94 | CA5A (0.38) | CA5ACA5BMAPTSMN1; SMN2KDM4E | |
| Trolamine SCHEMBL28711399 | 0.88 | MAPT (0.36) | CA5ACA5BMAPTSMN1; SMN2KDM4E | |
| Trolamine SCHEMBL11574269 | 0.88 | MAPT (0.34) | CA5ACA5BMAPTSMN1; SMN2KDM4E | |
| Trolamine SCHEMBL28711400 | 0.88 | MAPT (0.36) | CA5ACA5BMAPTSMN1; SMN2KDM4E | |
| Sulfuric Acid SCHEMBL28902821 | 0.86 | NPSR1 (0.35) | CA5ACA5BMAPTSMN1; SMN2KDM4E | |
| Trolamine SCHEMBL28225633 | 0.86 | SMN1; SMN2 (0.43) | CA5ACA5BMAPTSMN1; SMN2KDM4E | |
| Trolamine SCHEMBL11126659 | 0.85 | MAPT (0.36) | MAPTSMN1; SMN2KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113308934-B | Blending glue for super-matte deep relief impregnated paper, production process and application thereof | 上海贝辉木业有限公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-113308934-A | Blending glue for super-matte deep relief impregnated paper, production process and application thereof | 上海贝辉木业有限公司 | 2021-08-27 | — | — | CN | disclosed |
| CN-108689897-A | A kind of preparation method and application of the bigcatkin willow aldehydes schiff base compounds with fluorescent characteristic | 南京信息工程大学 | 2018-10-23 | — | — | CN | disclosed |
| CN-105671565-A | Rust removal process for steel surface | 重庆尚科机械制造有限公司 | 2016-06-15 | — | — | CN | disclosed |