Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 9/20 | 0.63 |
| ▸ | TUBB | P07437 | 9/20 | 0.63 |
| ▸ | TUBA3C | P0DPH7 | 9/20 | 0.63 |
| ▸ | TUBA1B | P68363 | 9/20 | 0.63 |
| ▸ | TUBA4A | P68366 | 9/20 | 0.63 |
| ▸ | TUBB4B | P68371 | 9/20 | 0.63 |
| ▸ | TUBB3 | Q13509 | 9/20 | 0.63 |
| ▸ | TUBB2A | Q13885 | 9/20 | 0.63 |
| ▸ | TUBB8 | Q3ZCM7 | 9/20 | 0.63 |
| ▸ | TUBA3E | Q6PEY2 | 9/20 | 0.63 |
| ▸ | TUBA1A | Q71U36 | 9/20 | 0.63 |
| ▸ | TUBA1C | Q9BQE3 | 9/20 | 0.63 |
| ▸ | TUBB6 | Q9BUF5 | 9/20 | 0.63 |
| ▸ | TUBB2B | Q9BVA1 | 9/20 | 0.63 |
| ▸ | TUBB1 | Q9H4B7 | 9/20 | 0.63 |
| ▸ | KRAS | P01116 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21005800 | 0.98 | TUBB4A (0.65) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9189623 | 0.98 | TUBB4A (0.65) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9189630 | 0.98 | TUBB4A (0.65) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL710997 | 0.89 | KRAS (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL710996 | 0.89 | KRAS (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL10385902 | 0.84 | PTGS1 (0.65) | TUBB1KRASPTGS1PTGS2KDM4E | |
| SCHEMBL22010235 | 0.83 | CYP1A1 (0.65) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL8854378 | 0.83 | CYP1A1 (0.65) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL3807860 | 0.82 | NFE2L2 (0.51) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL3807862 | 0.82 | NFE2L2 (0.51) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101506312-B | Dye composite containing thiol/disulfide fluorescent dye, this dyestuff is used to brighten white method by keratin material | 莱雅公司 | 2016-08-17 | — | — | CN | disclosed |