Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059200 | 0.86 | POLB (0.68) | MAPTPOLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14590442 | 0.84 | MAPT (0.55) | MAPTPOLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14626215 | 0.83 | MAPT (0.57) | MAPTPOLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14626136 | 0.82 | MAPT (0.56) | MAPTPOLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12929736 | 0.81 | ALDH1A1 (0.61) | MAPTPOLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25260381 | 0.81 | MAPT (0.48) | MAPTPOLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12929652 | 0.80 | ALDH1A1 (0.63) | MAPTPOLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14590422 | 0.80 | MAPT (0.63) | MAPTPOLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9051143 | 0.79 | POLB (0.51) | MAPTPOLBSMN1; SMN2ADORA1LMNA | |
| SCHEMBL9048339 | 0.79 | POLB (0.51) | MAPTPOLBSMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814049-B | Fused tricyclic imdazole derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-105814049-A | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |