Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28082086 | 1.00 | MAPT (0.48) | MAPTPOLBL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL31576683 | 0.86 | MAPT (0.56) | MAPTPOLBSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL10779520 | 0.86 | LMNA (0.48) | MAPTL3MBTL1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL10013411 | 0.86 | LMNA (0.48) | MAPTL3MBTL1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL10013412 | 0.86 | LMNA (0.48) | MAPTL3MBTL1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL28082102 | 0.84 | L3MBTL1 (0.46) | MAPTL3MBTL1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL28082101 | 0.84 | L3MBTL1 (0.46) | MAPTL3MBTL1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL28082113 | 0.84 | L3MBTL1 (0.46) | MAPTL3MBTL1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL18128002 | 0.83 | MAPT (0.52) | MAPTPOLBL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10976558 | 0.80 | L3MBTL1 (0.53) | MAPTL3MBTL1SMN1; SMN2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814054-A | Fused imidazole and pyrazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |