Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574448 | 0.82 | KDM4E (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL574453 | 0.67 | PTGES2 (0.54) | KMT2APTGES2ACLYSMN1; SMN2 | |
| SCHEMBL12482335 | 0.66 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12482621 | 0.65 | PSEN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16467751 | 0.65 | PKM (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22145974 | 0.64 | KMT2A (0.39) | KMT2ATDP1PKM | |
| SCHEMBL124345 | 0.64 | ALDH1A1 (0.33) | KDM4EKMT2ATDP1 | |
| SCHEMBL29867689 | 0.64 | KMT2A (0.31) | KMT2ATDP1 | |
| SCHEMBL15198327 | 0.62 | C5AR1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL30993876 | 0.61 | ACLY (0.45) | KMT2AACLYMEN1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103403002-B | Thiazolylphenyl-benzderivativesido derivativesido as inhibitors of kinases | 内尔维阿诺医学科学有限公司 | 2016-06-22 | — | — | CN | disclosed |